Impact of Eccentric Training Conducted in the Conditions of Normobaric Hypoxia, Normoxia and Creatine Supplementation on Metabolic Control, Muscle Strength Level, Maximum Oxygen Consumption (VO2max) in Patients With Type 1diabetes Mellitus
Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Exercise plays an important role in treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation and also commercially. The aim of the study is to assess the impact of eccentric training conducted in conditions of normobaric hypoxia or normoxia and creatine supplementation on metabolic control: profile and stability of glucose concentration, HbA1c value, hypoglycemia and insulin demand, as well as the level of muscle strength, VO2max and anthropometric parameters
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 20
Maximum Age: 45
Healthy Volunteers: f
View:
• type 1 diabetes of at least 10 years duration,
• low physical activity,
• BMI:20-31 kg/m2,
• treated with multiple insulin injections (at least 4 daily) or insulin pump (continuous subcutaneous insulin infusion \[CSII\]),
• negative ECG exercise test,
• HbA1c ≤ 8,0%,
• high knowledge about functional insulin therapy, carbohydrate counting and diabetes management during exercise,
• experience in use of FreeStyleLibre2 (Flash Glucose Monitoring System, Abbott),
• Informed consent to participate in research signed by enrolled subjects
Locations
Other Locations
Poland
Department of Internal Diseases, Diabetology and Cardiometabolic Disorders, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland
RECRUITING
Zabrze
Contact Information
Primary
Marta Wróbel, MD,PhD
mwrobel@sum.edu.pl
+46606873060
Backup
Paula Nowocień, MD
paula.nowocien@protonmail.com
48695219960
Time Frame
Start Date:2023-11-15
Estimated Completion Date:2025-07
Participants
Target number of participants:28
Treatments
Experimental: 1. exercise in hypoxia with creatine supplementation
* training program in normobaric hypoxic chamber set to contain equivalent to an altitude of 2500 meters above sea level (indoor air composition: 15,4% of O2 and 84,7% of N)~* with creatine supplementation
Experimental: 2. exercise in hypoxia without creatine supplementation
* training program in normobaric hypoxic chamber set to contain equivalent to an altitude of 2500 meters above sea level (indoor air composition: 15,4% of O2 and 84,7% of N)~* without creatine supplementation
Experimental: 3. exercise in normoxia with creatine supplementation
* the same training program in normoxic conditions~* with creatine supplementation
Experimental: 4.exercise in normoxia without creatine supplementation
* the same training program in normoxic conditions~* without creatine supplementation